N’-(2-(5-((Theophylline-7-yl)methyl)- 4-ethyl-1,2,4-triazole-3-ylthio)acetyl) isonicotinohydrazide As Antitubercular Agents

Authors : Andrey GOTSULYA, Vladimir ZAZHARSKYI, Volodymyr PARCHENKO, Pavel DAVYDENKO, Oleg KULISHENKO, Tetyana BRYTANOVA

Pages : 149-155

Doi:10.52794/hujpharm.1011368

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Publication Date : 2022-09-01

Article Type : Research Paper

Abstract :The paper presents the results of histological studies of tuberculosis in rabbits in an experimental model with comparative treatment with isoniazid and N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotinohydrazide. The calculated dose of N'-(2-(5-((theophylline-7-yl)methyl)-4-ethyl-1,2,4-triazole-3-ylthio)acetyl)isonicotino-hydrazide for subcutaneous administration indicates its prospects for veterinary practice as an effective and safe tuberculocidal drug.
Keywords : tuberculosis, experimental model, rabbits, 1, 2, 4 triazole