Green Synthesis of Biocompatible Hybrid Ginger/Chitosan Carbon Nanodot Exhibiting Antiproliferative Activity on Carcinoma Cells

Authors : Hasan İLHAN

Pages : 1916-1925

Doi:10.21597/jist.1249897

View : 53 | Download : 49

Publication Date : 2023-09-01

Article Type : Research Paper

Abstract :Carbon Nanodots insert ignore into journalissuearticles values(CDs);-modified chitosan and ginger insert ignore into journalissuearticles values(ginger/chitosan@CD); based biocompatible substrate was built with the purpose of assessing antiproliferation effect on prostate cancer cell line insert ignore into journalissuearticles values(PC-3);, human prostate adenocarcinoma cell line insert ignore into journalissuearticles values(LNCaP);, and breast cancer cell line insert ignore into journalissuearticles values(MCF-7);. CDs were fabricated through a solvothermal synhesis process, and characterized with TEM, SERS, and UV-vis spectroscopy. In this study, the cytotoxic impact of ginger/chitosan CD, which was synthesized for the first time, was evaluated as a function of both dose insert ignore into journalissuearticles values(maximum concentration 500 μg/mL); and time insert ignore into journalissuearticles values(in 24 and 48 hours); in cancer cell lines by XTT assay. After 48 hours, the ginger/chitosan@CD combination was found to have a 50% inhibitory concentration insert ignore into journalissuearticles values(IC50); of 178.08 μg/mL in the PC-3 cell line, 246.44 μg/mL in the LNCaP prostate cancer cells, and 345.74 μg/mL in the MCF-7. Cancer cell proliferation was efficiently suppressed by the ginger/chitosan@CDs.
Keywords : Carbon nanodot, ginger, chitosan, Cancer cell lines, XTT