İnflamatuvar barsak hastalıkları aktivitesi ile serum neopterin düzeyi arasındaki ilişki

Authors : İbrahim ERTUĞRUL, Ömer Faruk YOLCU, Salih CESUR, Ülkü DAĞLI, Ömer BAŞAR, İlhami YÜKSEL, Başak ÇAKAL, Yasemin Ö. ÖZİN, Mehmet İBİŞ, Hilmi ATASEVEN, Bilge TUNÇ, Aysel ÜLKER, Nurgül ŞAŞMAZ

Pages : 56-61

View : 17 | Download : 5

Publication Date : 2007-08-01

Article Type : Research Paper

Abstract :Background/aims: The etiology of inflammatory bowel diseases, chronic intestinal diseases characterized by remissions and activation periods, is still unknown. Identification of the active period is important because it guides the therapy and point outs the prognosis. To date, there is still a lack of agreement on determining the active state. Neopterin is produced in monocytes/macrophages primarily upon stimulation with interferon-gamma. It is a marker associated with cell-mediated immunity. The aim of this study was to investigate the role of serum neopterin levels in Crohn's disease and ulcerative colitis disease activity. Materials and methods: Sixty-one patients with ulcerative colitis (21 female, 40 male) and 27 patients with Crohn's disease (9 female, 18 male) who were followed up at Türkiye Yüksek İhtisas Hospital were enrolled into the study. Fiftytwo healthy controls (22 female, 30 male) were also enrolled. Neopterin is measured by enzyme-linked immunosorbent assay. Serum levels >10 nmol/L are regarded as elevated. Patients with malignancy and systemic infectious diseases were not included in the study. For statistical analysis, one-way ANOVA, Pearson correlation analysis test, Fisher's exact test, Mann-Whitney U test and Student's test were used. Significance was established at p
Keywords : Neopterin, inflamatuvar barsak hastalığı, crohn hastalığı, ülseratif kolit