Second-Third Trimester Aspartate Aminotransferase to Platelet Ratio Index in Predicting in Intrahepatic Cholestasis of Pregnancy and its Relationship with Neoanatal Intensive Care Unit Requirement: A Case Control Study From a Tertiary Hospital

Authors : Bedri SAKCAK, Ramazan DENİZLİ, Nihat FARİSOĞULLARI, Göksun İPEK, Özgür KARA, Atakan TANACAN, Dilek SAHİN

Pages : 1863-1866

Doi:10.38136/jgon.1231865

View : 48 | Download : 37

Publication Date : 2023-10-01

Article Type : Research Paper

Abstract :Aim: To evaluate the aspartate aminotransferase platelet ratio index insert ignore into journalissuearticles values(APRI); score in the prediction of intrahepatic cholestasis insert ignore into journalissuearticles values(ICP); in the second-third trimester of pregnancy. Material and Methods: The patient group insert ignore into journalissuearticles values(n=40); and control group insert ignore into journalissuearticles values(n=70); diagnosed with ICP who applied to the hospital Perinatology clinic between 2021-2022 were included in this study. Laboratory tests of both groups were analyzed retrospectively. Age, gravida, parity, body mass index, third trimester laboratory tests and first trimester aspartate aminotransferase insert ignore into journalissuearticles values(AST);/platelet count ratio [AST - platelet ratio index insert ignore into journalissuearticles values(APRI); score] APRI scores were compared between the two groups. The relationship between APRI score index and neonatal outcomes was evaluated in the study group.In the study, the cut-off value of the APRI score was determined for predicting ICP in second-third trimester in pregnant women. Results: Patients with ICP had significantly higher APRI scores compared with controls insert ignore into journalissuearticles values(p <0.001);. In the ROC analysis, the cut-off value for APRI score to predicting ICP in second-third trimester was 0.092 with 78 % sensitivity and 79 % specificity. Spearman’s correlation indicated that there was a significant positive association between APRI score and neonatal intensive care unit insert ignore into journalissuearticles values(NICU); requirement in the study group insert ignore into journalissuearticles values(p=0.022);. The demographic characteristics of patients did not differ, except for aspartateamino transferase and alanine transferase values. Conclusions: APRI score may be used in the prediction of ICP development and NICU requirement with satisfactory sensitivity and specifity. As ICP is associated with poor perinatal outcomes, this novel index may help physicians in their clinical practice to obtain more favorable outcomes.
Keywords : APRI skoru, Serum açlık safra asidi, YYBÜ gereksinimi, Gebeliğin intrahepatik kolestazı