Relation Between Obstructive Sleep Apnea Syndrome and 25-Hydroxyvitamin D Levels in Patients at High Altitude

Authors : Kağan TUR, Eray ATALAY

Pages : 242-246

View : 17 | Download : 7

Publication Date : 2022-12-15

Article Type : Research Paper

Abstract :Aim: Present study’s objective is to investigate the relationship between serum 25-hydroxyvitamin D and the severity of sleep apnea at altitude. Material and Method: Fifty obstructive sleep apnea syndrome patients and 18 persons without apnea participated in this study. Apnea Hypopnea Index scores were measured with polysomnography during the night and classified as AHI<15: control, 15≥AHI<30 moderate, and AHI≥30 severe obstructive sleep apnea. In addition, the serum 25-hydroxyvitamin D levels of the patients were also measured. Results: In the logistic regression analysis, it was found that there was an independent correlation between the apnea-hypopnea index and 25-hydroxyvitamin D insert ignore into journalissuearticles values(AUROC=0.658, p=0.028);. We found a significant difference between the control and obstructive sleep apnea groups for 25-hydroxyvitamin D insert ignore into journalissuearticles values(p<0.05);. A significant relationship has been found between moderate and severe obstructive sleep apnea groups for vitamin D deficiency and average vitamin D insert ignore into journalissuearticles values(p<0.0001);. Conclusion: We found an independent association between 25-hydroxyvitamin D and obstructive sleep apnea severity at high altitudes. An interesting point of our study is that our study has been conducted at a high altitude region with an elevation of more than 1768 meters. Therefore, effective vitamin D management may help prevent obstructive sleep apnea syndrome development, and patients’ medical status can be improved.
Keywords : 25 Hydroxyvitamin D, polysomnography, obstructive sleep apnea syndrome, altitude