- Kafkas Tıp Bilimleri Dergisi
- Volume:13 Issue:2
- The Effect of Vaccination on Biochemical and Inflammatory Markers in Hospitalized COVID-19 Patients
The Effect of Vaccination on Biochemical and Inflammatory Markers in Hospitalized COVID-19 Patients
Authors : Pelin Pınar DENİZ, İsmail HANTA, Pelin Duru ÇETİNKAYA, Orhan ALTINÖZ, Yeşim TAŞOVA, Burak METE
Pages : 155-159
View : 31 | Download : 30
Publication Date : 2023-08-25
Article Type : Research Paper
Abstract :Aim: Coronavirus disease 2019 insert ignore into journalissuearticles values(COVID-19); vaccines have been proven beneficial in preventing hospitalization, serious illness, and death. However, whether immunization affects biochemical and inflammatory markers, prognostic factors in hospitalization remain unknown. The effects of vaccination status on blood biochemistry and inflammatory markers were investigated in our study of patients hospitalized with COVID-19. Material and Method: A total of 107 patients comprising 67 unvaccinated and 40 vaccinated individuals who were hospitalized for COVID-19 from two different centers between November 1, 2021, and January 1, 2021, were included in our study. The patients’ demographics, comorbidities, and biochemical and inflammatory markers were recorded during hospitalization. Results: We identified 107 patients insert ignore into journalissuearticles values(62 men and 45 women; mean age, 63.7±14.8 years);, with a mean age of 68.6±12.2 insert ignore into journalissuearticles values(37–89); and 60.7±15.5 insert ignore into journalissuearticles values(27–88); for the vaccinated and unvaccinated groups insert ignore into journalissuearticles values(p=0.005);, respectively. Lymphocyte level in the 0–55 age group was 1.4±0.46×109/L in vaccinated patients and 0.96±0.5×109/L in unvaccinated patients. The difference was statistically significant insert ignore into journalissuearticles values(p=0.05);. The lactate dehydrogenase insert ignore into journalissuearticles values(LDH); value was higher in the unvaccinated patients in all age groups insert ignore into journalissuearticles values(0–55 and over 55 years old); insert ignore into journalissuearticles values(p=0.04);. Using logistic regression analysis, LDH was demonstrated to be a predictive factor for admission to the intensive care unit insert ignore into journalissuearticles values(ICU); in the 0–55 age range of unvaccinated patients. It was determined that the increase in LDH in all age groups elevates the ICU admission risk by 1.004 times. Conclusion: Our study showed that COVID-19 vaccination is effective against lymphopenia induced by COVID-19 in people under 55 and LDH in people of all ages. The impact of vaccination status on LDH may be meaningful, considering that elevated LDH has been associated with a higher risk of ICU support, mortality, and complications.Keywords : COVID 19, COVID 19 vaccine, lactate dehydrogenase, lymphopenia