PROLIDASE ACTIVITY AND OXIDATIVE STRESS IN BENIGN, PRE-MALIGNANT AND MALIGNANT ENDOMETRIAL LESIONS

Authors : Mesut KÖSE, Ayhan VURMAZ, Yasemin ÇELİK

Pages : 195-200

Doi:10.18229/kocatepetip.1105749

View : 7 | Download : 1

Publication Date : 2023-04-05

Article Type : Research Paper

Abstract :OBJECTIVE: The present study aims to investigate the prolidase activity, total oxidant status insert ignore into journalissuearticles values(TOS); and total anti-oxidant status insert ignore into journalissuearticles values(TAS); in women who have been diagnosed with benign, pre-malignant and malignant endometrial pathologies. MATERIAL AND METHODS: Ninety women who underwent endometrial biopsy due to abnormal uterine bleeding were divided into three groups according to their histopathological findings: Benign endometrial pathology insert ignore into journalissuearticles values(n=65);, endometrial hyperplasia insert ignore into journalissuearticles values(n=12); and endometrial cancer insert ignore into journalissuearticles values(n=13);. These groups were compared with respect to oxidative stress markers and prolidase activity in serum and endometrial tissue. RESULTS: When compared to the benign endometrial pathology group, the endometrium cancer group had significantly higher age, shorter height and higher incidences of menopause and positive family history for gynecological malignancy insert ignore into journalissuearticles values(p=0.001, p=0.023, p=0.001 and p=0.001);. When compared to the benign endometrial pathology group, tissue prolidase activity was significantly higher in the endometrium hyperplasia and endometrium cancer groups insert ignore into journalissuearticles values(p=0.001 for both);. However, tissue prolidase activity was statistically similar in the endometrial hyperplasia and endometrial cancer groups insert ignore into journalissuearticles values(p=0.166);. All study groups had statistically similar serum prolidase activity, serum and tissue TOS, serum and tissue TAS, tissue malondialdehyde and glutathione values. CONCLUSIONS: Prolidase activity in endometrial tissue has enhanced in pre-malignant and malignant endometrial lesions when compared to benign endometrial lesions. The assessment of prolidase activity in endometrial tissue might help to distinguish pre-malignant and malignant lesions in case histopathological characteristics are insufficient for the differentiation of endometrial lesions.
Keywords : Biyopsi, Endometrium kanseri, Hiperplazi, Oksidatif stres, Prolidaz aktivitesi