Effects of 3-Benzoyl-7-Hydroxy Coumarin Compound on TNF-α and Caspase-3 Immunreactivity in Kidneys of Rats Exposed to Aluminum

Authors : Ahmet TÜRK, Tuncay KULOĞLU, Büşra ZENCİRCİ, Ali GÜREL, Abdullah KARADAĞ, Yusuf ÖZAY, Serhat HANÇER, Muhammed Emre YÜZER, Kenan TÜRKAN, Ahmet ÖZKAYA

Pages : 73-78

Doi:10.31594/commagene.1217426

View : 48 | Download : 44

Publication Date : 2023-06-30

Article Type : Research Paper

Abstract :In this study, we aimed to investigate the effects of 3-benzoyl-7-hydroxy coumarin compound on apoptotic markers in the kidney tissues of rats treated with Aluminuminsert ignore into journalissuearticles values(Alu);. 28 Wistar albino male rats were divided into four groups insert ignore into journalissuearticles values(n = 7); as: Control Group: 1 ml/kg 0.9% NaCl was administered by oral gavage every other day during the experiment. Aluminium insert ignore into journalissuearticles values(Alu); Group: Alu was prepared in water and given by intraperitonealinsert ignore into journalissuearticles values(i.p); for 30 days at an excess of 8.3 mg/kg/day. Treatment Group: 10 mg/kg 3-Benzoyl-7-Hydroxy Coumarin was administered to rats by oral gavage every other day for 30 days. Alu + Treatment Group: 8.3 mg/kg Alu was prepared in water and administered i.p for 30 days every other day, and then 10 mg/kg 3-Benzoyl-7-Hydroxy Coumarin was administered to rats by oral gavage every other day for 30 days. At the end of the 30-day experiment, the kidney tissue of the animals were removed under anesthesia and stored under appropriate conditions. In according to our data, Alu administration caused increased Caspase-3 TNF-α and MDA levels in kidney tissue, and 3-benzoyl-7-hydroxy coumarin was found to significantly reverse these changes.
Keywords : Oksidatif stres, Apoptoz, Proinflamatuar sitokin, İmmünohistokimya