25-Hydroxyvitamin D Levels in Preterm Infants ≤32 Weeks Gestational Age and Respiratory Distress Syndrome

Authors : Erbu YARCI, Emre BALDAN

Pages : 259-264

Doi:10.53394/akd.1031158

View : 33 | Download : 33

Publication Date : 2023-09-01

Article Type : Research Paper

Abstract :Objective: The aim of this study was to evaluate neonatal vitamin D status and effect of vitamin D levels on the development of respiratory distress syndrome insert ignore into journalissuearticles values(RDS); in preterm infants with a gestational age of ≤ 32 weeks. The association between RDS and severity of vitamin D deficiency was secondary outcome of this study. Method: Newborns having a gestational age of ≤32 weeks with RDS consisted the study group, while newborns hospitalized in the neonatal intensive care unit having ≤32 weeks of gestational age with no signs of RDS were the control group. Results: During the study period, 122 preterm infants having a gestational age of ≤ 32 weeks were included. From these, 56 insert ignore into journalissuearticles values(46%); had RDS insert ignore into journalissuearticles values(study group);, while 66 insert ignore into journalissuearticles values(54%); newborns insert ignore into journalissuearticles values(control group); did not have RDS. There was no significant difference between the groups in terms of maternal age, multiple pregnancy, use of antenatal steroid, sex, mode of delivery, maternal age, antenatal steroid use, accompanying maternal diseases and birth season. Median 25-OHD levels of study group and control group were similar insert ignore into journalissuearticles values(12.3 ng/ml vs 15.6 ng/ml; p=0.38);. The rates of preterm infants having low vitamin D levels insert ignore into journalissuearticles values(25-OHD level<15 ng/ml); did not differ between the groups insert ignore into journalissuearticles values(38/56, 68% vs 35/66, 53%; p=0.09);. Conclusions: There is no established optimal 25-OHD level for both term and premature infants. Besides, taking into account possible unfavorable both maternal and neonatal effects of vitamin D deficiency, adequate vitamin D supplementation should be provided in countries where vitamin D deficiency is common.
Keywords : 25 hidroksivitamin D, preterm bebek, respiratuvar distres sendromu