Determining the Risk of Gestational Diabetes Mellitus: Evaluation of the Role of Complete Blood Count Variables Measured in the First Two Trimesters

Authors : Elvan Yakupoğlu, Murat Altuntas

Pages : 216-224

Doi:10.53394/akd.1198449

View : 32 | Download : 46

Publication Date : 2024-05-01

Article Type : Research Paper

Abstract :Objective: To evaluate the value of first and second trimester complete blood count (CBC) parameters in predicting the risk of gestational diabetes mellitus (GDM). Materials and Method: This study was carried out from January 2017 to December 2018 at the XXX. The CBC and biochemistry results, various indices calculated from CBC parameters, and other data of the study group consisting of pregnant women with and without GDM were obtained from medical records. Results: Age (p<0.001), fasting glucose (p<0.001), red blood cell count (RBC) (p<0.001), hemoglobin (p=0.015), hematocrit (p<0.001), red cell distribution width (RDW) (p=0.001), RDW-to-platelet ratio (p<0.001), and all glucose levels for 75 g OGTT tests (p<0.001 for all) were higher in women with GDM compared to controls. Platelet count (p=0.002), platelet-to-lymphocyte ratio (p=0.006) and platelet-to-MPV ratio (p=0.021) were lower in pregnant women with GDM compared to those without. We found high age (p<0.001), high RBC (p=0.002) and high RDW-to-platelet ratio (p<0.001) were independently associated with GDM. For the prediction of GDM, the area under curve (AUC) values were highest for RBC (AUC:0.619, 95%CI: 0.566-0.673; p<0.001) and RDW-to-platelet ratio (AUC:0.610, 95%CI: 0.556-0.663; p<0.001). RBC showed 57.0% sensitivity and 63.4% specificity, while RDW-to-platelet ratio demonstrated 31.7% sensitivity and 89.2% specificity. Conclusion: Increased RBC and increased RDW-to-platelet ratio measured in the early period of pregnancy are independent predictors of higher GDM risk. Comprehensive prospective studies assessing early determinants of GDM risk are needed.
Keywords : Gestasyonel diyabet, Risk, Tam kan sayımı