Secondary Bacterial Agents and Antibiotic Resistance Profiles in Respiratory Tract Specimens of Patients with COVID-19 Pneumonia

Authors : Oya AKKAYA, Ayşe Rüveyda UĞUR, Habibe ÖVET, Feyza ALP, Mustafa Önder GÖNEN

Pages : 39-46

Doi:10.26453/otjhs.1094238

View : 12 | Download : 6

Publication Date : 2023-03-05

Article Type : Research Paper

Abstract :Objective: To assess secondary bacterial pneumonia agents and antibiotic resistance rates in patients with COVID-19 pneumonia and to compare findings with the pre-pandemic period. Materials and Methods: Bacteria grown in endotracheal aspirate fluid and bronchoalveolar fluid samples of patients diagnosed with COVID-19 between January 2020 and December 2020, and antibiotic resistance rates were retrospectively compared with samples of the year before the pandemic. Isolates were identified at the species level with an automated system insert ignore into journalissuearticles values(VITEK 2, bioMérieux, France);, and antimicrobial susceptibility was determined according to EUCAST criteria. Results: A total of 900 culture results were examined in 2019. Acinetobacter baumannii was detected in 36%, Klebsiella pneumoniae in 23%, Pseudomonas aeruginosa in 14%, and Staphylococcus aureus in 8%. In 2020, 660 culture results were examined, and the same bacteria were detected in 43%, 23%, 16%, and 5%, respectively. K. pneumoniae\`s resistance to third-generation cephalosporins, and A. baumannii\`s resistance to gentamycin and tobramycin, were found to have increased significantly during the pandemic period. Conclusions: The growth of multidrug-resistant Gram-negative bacteria was frequently detected in respiratory secretions obtained during the COVID-19 pandemic. Regional bacterial agents and antibiotic resistance profiles should be clarified, and empirical therapy should be selected accordingly in COVID-19.
Keywords : Antibiyotik direnci, bakteriyel süperenfeksiyon, COVID 19, pnömoni, yoğun bakım ünitesi