Association and Haplotype Analysis of the PON1, ITGB3 and CYP3A4 Genes, Strong Candidates for Familial Coronary Artery Disease Susceptibility

Authors : Faruk SAYDAM, İrfan DEĞİRMENCİ, Alparslan BİRDANE, Cansu ÖZBAYER, Taner ULUS, Mahmut ÖZDEMİR, Necmi ATA, Hasan Veysi GÜNEŞ

Pages : 81-88

Doi:10.26453/otjhs.1165494

View : 18 | Download : 6

Publication Date : 2023-03-05

Article Type : Research Paper

Abstract :Objective: Genetic predisposition is very common among the patients with coronary artery disease insert ignore into journalissuearticles values(CAD);, a complex and multifactorial disease. Our objective was to determine the possible association between the most remarkable functional variants in the paraoxonase 1insert ignore into journalissuearticles values(PON1);, cytochrome P450 3A4 insert ignore into journalissuearticles values(CYP3A4);, integrin subunit beta 3 insert ignore into journalissuearticles values(ITGB3); genes and familial CAD. Materials and Methods: We included 117 patients diagnosed with familial CAD and 99 healthy subjects with no family history of CAD. PON1 Q192R, PON1 L55M, CYP3A4*1G and ITGB3 L33P single nucleotide polymorphisms were genotyped using the Sequenom MassARRAY system. Results: Comparison of genotype and allele frequencies in inheritance models of polymorphisms between the patient and control groups did not reveal any significant findings related to CAD. Stratified analysis by gender did also not display any association both in females and males. There was no significant difference in the frequencies of the haplotypes of the PON1 Q192R and L55M polymorphisms between the groups. Conclusions: Our findings confirmed previous studies that did not consider PON1, CYP3A4 and ITGB3 genes as risk loci. The fact that our study was conducted only in patients with familial CAD shows the originality and importance of our results.
Keywords : Ailesel koroner arter hastalığı, CYP3A4, PON1, ITGB3